After paracetamol overdose, when AST and ALT exceed 1000 IU L, paracetamol-induced hepatotoxicity can be diagnosed. Laboratory studies may show evidence of massive hepatic necrosis with elevated AST, ALT, bilirubin, and prolonged coagulation times particularly, elevated prothrombin time. Stability of the Drug to Temperature, Light, and Moisture Acetaminophen is stable to temperature, light, and moisture. Once it has been determined that potentially toxic overdose has occurred, acetylcysteine is continued for the entire regimen, even after the paracetamol level becomes undetectable in the blood. Quote8:Pending the results of such paracetamol halpaa research, paracetamol remains the preferred drug to relieve pain and fever in childhood. Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of paracetamol 4-acetamidophenol. In many cases, the hepatic necrosis may run its course, hepatic function may return, and the patient may survive with liver function returning to normal in few weeks.
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